Seeing the Unseen
Research
Our vision
Modern optical microscopy has revolutionized the way researchers study biological systems. Vibrational microscopy emerges as the new frontier of bio-optical imaging and profiling, considering its unique strength in imaging chemical bonds. Meanwhile, vibrational probes and related sample engineering are under active development, extending vibrational imaging to new territories. Our research is at the interplay of biophotonics, chemistry, bioengineering and data science, focusing on developing advanced vibrational spectroscopy and microscopy, together with novel probes and machine learning strategies, to interrogate the complexity of biological systems in a spatio-temporal manner. We are also interested in leveraging these technology advances into clinical applications.
Novel Biotechnologies
Enhance performance by pushing sensitivity, spatial resolution, imaging depth, information content, etc
Leveraging advanced vibrational spectroscopy and microscopy to clinical applications
Metabolic Imaging and Profiling
Single-cell phenotypic profiling
Large-area tissue/organ metabolic mapping with cell-type and cell-state specificity
Vibrational Sensing on Local Environment
How biophysical properties change over important processes and its correlation with biomolecular and cell functions.
